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KMID : 0545120170270020262
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Journal of Microbiology and Biotechnology
2017 Volume.27 No. 2 p.262 ~ p.270
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Genomic Insights and Its Comparative Analysis with Yersinia enterocolitica Reveals the Potential Virulence Determinants and Further Pathogenicity for Foodborne Outbreaks
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Gnanasekaran Gopalsamy
Na Eun-Jung
Chung Han-Young
Kim Su-Yeon
Kim You-Tae
Kwak Woo-Ri
Kim Hee-Bal
Ryu Sang-Ryeol
Choi Sang-Ho
Lee Ju-Hoon
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Abstract
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Yersinia enterocolitica is a well-known foodborne pathogen causing gastrointestinal infections worldwide. The strain Y. enterocolitica FORC_002 was isolated from the gill of flatfish (plaice) and its genome was sequenced. The genomic DNA consists of 4,837,317 bp with a GC content of 47.1%, and is predicted to contain 4,221 open reading frames, 81 tRNA genes, and 26 rRNA genes. Interestingly, genomic analysis revealed pathogenesis and host immune evasionassociated genes encoding guanylate cyclase (Yst), invasin (Ail and Inv), outer membrane protein (Yops), autotransporter adhesin A (YadA), RTX-like toxins, and a type III secretion system. In particular, guanylate cyclase is a heat-stable enterotoxin causing Yersinia-associated diarrhea, and RTX-like toxins are responsible for attachment to integrin on the target cell for cytotoxic action. This genome can be used to identify virulence factors that can be applied for the development of novel biomarkers for the rapid detection of this pathogen in foods.
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KEYWORD
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Yersinia enterocolitica, genome, Type III secretion system, virulence factor, food poisoning, gastroenteritis
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